I don't really know enough about 4e to know what it might be a suitable system for, though.
D&D 4E has often been accused by its detractors of having too many card game elements, and (as Hal has put it) every PC is basically a wizard, with super impressive magic powers that recharge at different rates.
On the other hand, several people have tried to cobble together a Magic: The Gathering
RPG over the years, with varying degrees of success. For those who may be unfamiliar with the game, M:tG is a collectible card game, where everyone plays... yes, you guessed it: a wizard.
Perhaps you could combine two problems to create one solution, here?